Efficient Methods for the Synthesis
of Thieno[3,2-b]thiophene
and Thieno[3,2-b]furan
Derivatives

Valerii Z. Shirinian; Alexey A. Shimkin; Stepan N. Tipikin; Mikhail M. Krayushkin

doi:10.1055/s-0029-1217019

PAPER

Efficient Methods for the Synthesis of Thieno[3,2-b]thiophene and Thieno[3,2-b]furan Derivatives

Valerii Z. Shirinian*, Alexey A. Shimkin, Stepan N. Tipikin, Mikhail M. Krayushkin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
Fax: +7(499)1355328; e-Mail: shir@ioc.ac.ru;

Abstract

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Abstract

A novel approach to the synthesis of thieno[3,2-b]thiophenes and thieno[3,2-b]furans bearing various substituents from readily accessible starting materials has been developed. The methodology is based on C- and O-alkylation of ethyl 4-hydroxy-2-methylthiophene-3-carboxylate with α-halo ketones, followed by cyclization.

Key words

alkylation - cyclization - heterocycles - thienothiophenes - thienofurans

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References

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